Meta-Analysis of Breast Cancer Risk for Individuals with PALB2 Pathogenic Variants.
Ruberu TLM, Braun D, Parmigiani G, Biswas S.
medRxiv. 2024 Mar 04. PMID: 37398422
Primary Faculty
Giovanni Parmigiani
Overview
Models and software for predicting who is at risk of carrying genetic variants that confer susceptibility to cancer. Application to breast, ovarian, colorectal, pancreatic and skin cancer.
Statistical methods for the analysis of high throughput genomic data: analysis of cancer genome sequencing projects; integration of genomic information across technologies; cross-study validation of genomics results.
Statistical methods for comparative effectiveness research: comprehensive models for lifetime history of chronic disease outcomes; Bayesian meta-analysis; Bayesian causal inference; decision analysis.
Bayesian modeling and computation: multilevel models; decision theoretic approaches to inference; sequential experimental design and their application to adaptive and multistage studies in clinical and epidemiological research.
Bibliography
Optimal ensemble construction for multistudy prediction with applications to mortality estimation.
Loewinger G, Nunez RA, Mazumder R, Parmigiani G.
Stat Med. 2024 Feb 23. PMID: 38396313
MSGene: Derivation and validation of a multistate model for lifetime risk of coronary artery disease using genetic risk and the electronic health record.
Urbut SM, Yeung MW, Khurshid S, Cho SMJ, Schuermans A, German J, Taraszka K, Fahed AC, Ellinor P, Trinquart L, Parmigiani G, Gusev A, Natarajan P.
medRxiv. 2023 Nov 08. PMID: 37986972
Bayesian combinatorial MultiStudy factor analysis.
Grabski IN, Vito R, Trippa L, Parmigiani G.
Ann Appl Stat. 2023 Sep. 17(3):2212-2235. PMID: 37786772
Clinical implications of conflicting variant interpretations in the cancer genetics clinic.
Zukin E, Culver JO, Liu Y, Yang Y, Ricker CN, Hodan R, Sturgeon D, Kingham K, Chun NM, Rowe-Teeter C, Singh K, Zell JA, Ladabaum U, McDonnell KJ, Ford JM, Parmigiani G, Braun D, Kurian AW, Gruber SB, Idos GE.
Genet Med. 2023 Jul. 25(7):100837. PMID: 37057674
High-dose melphalan treatment significantly increases mutational burden at relapse in multiple myeloma.
Samur MK, Roncador M, Aktas Samur A, Fulciniti M, Bazarbachi AH, Szalat R, Shammas MA, Sperling AS, Richardson PG, Magrangeas F, Minvielle S, Perrot A, Corre J, Moreau P, Thakurta A, Parmigiani G, Anderson KC, Avet-Loiseau H, Munshi NC.
Blood. 2023 04 06. 141(14):1724-1736. PMID: 36603186
Variant-specific Mendelian Risk Prediction Model.
Bae E, Dias JA, Huang T, Chen J, Parmigiani G, Rebbeck TR, Braun D.
bioRxiv. 2023 Mar 08. PMID: 36945459
Combining Breast Cancer Risk Prediction Models.
Guan Z, Huang T, McCarthy AM, Hughes K, Semine A, Uno H, Trippa L, Parmigiani G, Braun D.
Cancers (Basel). 2023 Feb 08. 15(4). PMID: 36831433
Cross-Study Replicability in Cluster Analysis.
Masoero L, Thomas E, Parmigiani G, Tyekucheva S, Trippa L.
Stat Sci. 2023 May. 38(2):303-316. PMID: 37885824
MyLynch: A Patient-Facing Clinical Decision Support Tool for Genetically-Guided Personalized Medicine in Lynch Syndrome.
Knapp ST, Revette A, Underhill-Blazey M, Stopfer JE, Ukaegbu CI, Poulin C, Parenteau M, Syngal S, Bae E, Bickmore T, Hampel H, Idos GE, Parmigiani G, Yurgelun MB, Braun D.
Cancers (Basel). 2023 Jan 06. 15(2). PMID: 36672340
News
Twin study estimates familial risks of 23 different cancers
For immediate release: Tuesday, January 5, 2016 Boston, MA – A large new study of twins has found that having a twin sibling diagnosed with cancer poses an excess risk for the other twin to develop any form of…
Researchers help Boston Marathon organizers plan for 2014 race
For immediate release: April 14, 2014 Chapel Hill, NC – After experiencing a tragic and truncated end to the 2013 Boston Marathon, race organizers were faced not only with grief but with hundreds of administrative decisions, including plans…
Prominent bioinformatics expert to join Harvard School of Public Health faculty and become chair of Dana-Farber Department of Biostatistics and Computational Biology
For immediate release: July 9, 2009 Boston, MA -- Giovanni Parmigiani, PhD, a noted leader in applying bioinformatics tools to cancer studies and medical decision-making, has been appointed professor of biostatistics at Harvard School of Public Health (HSPH)…